Information on your baby’s health. Affordable prenatal tests: on your time, on your terms.
Just like the Hazel™ Basic non-invasive prenatal screening test* (NIPS), Hazel™ Plus NIPS is performed using a small amount of blood from a finger prick, rather than a traditional blood draw. In addition to testing for fetal sex, Juno Hazel™ Plus screens your pregnancy for common chromosomal trisomies as well as differences in the number of sex chromosomes. Altogether, Hazel™ Plus NIPS offers prenatal screening for:
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edwards syndrome)
- Trisomy 13 (Patau syndrome)
- Sex chromosome aneuploidies:
- Monosomy X (Turner syndrome)
- XXY syndrome (Klinefelter syndrome)
- Trisomy X (Triple X syndrome)
- XYY syndrome (Jacobs syndrome)
Hazel™ Plus NIPS has no risk of miscarriage and can be performed as early as 9 weeks into pregnancy.
We’ll be here to support you from the moment we receive your order – before and after you receive results. So go ahead and enjoy all the exclusive benefits of choosing Juno, including:
- Flexible testing as early as 9 weeks
- Guided sample collection via video call, no guesswork!
- Easy-to-understand information about Hazel™, at your fingertips 24/7
- Informed consent for genetic screening – available anytime, anywhere through video resources
- >99% sensitivity and specificity rate for trisomies, >95% sensitivity rate for sex chromosome aneuploidies**
- Results within 2-4 business days of the lab receiving your sample
- Access to licensed & board-certified genetic counselors
- Free shipping and prepaid return label***
*NIPS is a screening test; screen positive (high risk) results should be confirmed through diagnostic testing.
**Through an assisted sample collection video call, our experts can ensure the highest quality results.
***Not available to Alaska, Hawaii, and Puerto Rico residents at this time.
Sex chromosome aneuploidy means a person has extra or missing sex chromosomes.
Females usually have 46 total chromosomes, including two X sex chromosomes. Males usually have 46 total chromosomes, including one X sex chromosome and one Y sex chromosome. A
So, a female with a sex chromosome aneuploidy might have one or three X chromosomes. A male with a sex chromosome aneuploidy might have two Xs and one Y, or one X and two Ys. The most common sex chromosome conditions are as follows:
- Monosomy X / Turner syndrome: People with monosomy X usually have only one X chromosome, and no Y chromosome. This condition can also be called Turner syndrome, and it’s seen in females. When a baby has monosomy X, there may be fetal complications like heart defects, fluid in the lungs and chest, and even miscarriage. While less common, some babies with monosomy X have no fetal complications. As the years go by, girls with monosomy X tend to be shorter than their siblings, and usually have infertility.
- XXY / Klinefelter syndrome: People with Klinefelter syndrome have two X chromosomes and one Y chromosome. This condition is seen in males – the extra X chromosome doesn’t usually cause differences in the appearance of male genitalia at birth. Many boys with Klinefelter syndrome will not have obvious physical differences from their brothers. But, as they get older, boys with Klinefelter syndrome tend to be taller and less muscular, with wider hips, less body hair, and more breast tissue. They usually have infertility unless special fertility treatment is pursued during adolescence.
- Triple X syndrome / Trisomy X: Triple X syndrome, also known as Trisomy X, describes a female with three X chromosomes. Most girls with Triple X syndrome will not have birth defects or other obvious features of their condition or birth defects. Some babies with Triple X will have low muscle tone, and as she grows up, a girl with Triple X might be a bit taller than her sisters. Most girls with this diagnosis do not have intellectual disability, but can have learning difficulties, such as dyslexia. Women with Triple X syndrome usually have typical fertility, but puberty problems and premature ovarian failure are possible.
- XYY /Jacob's syndrome: XYY syndrome, also called Jacob’s syndrome, describes a male with one X and two Y chromosomes. Males with XYY syndrome often grow to be taller than their siblings, but they typically look like other baby boys at birth and most will not have birth defects or obvious features of their condition. A diagnosis of XYY syndrome does not usually cause intellectual disability, but it can be associated with delayed language development, dyslexia, and behavioral concerns such as attention deficit hyperactivity disorder and impulsivity.
Greater than 99% sensitivity and specificity for the detection of trisomy 21, 18, and 13. Greater than 95% sensitivity and 99% specificity for the detection of sex chromosome aneuplodies.
Testing as early as 9 weeks into your pregnancy and can be done with your provider or through our Zoom-assisted sample collection.
Once your sample is returned to our laboratory, you'll receive fast results in as little as 2 to 4 business days.
About Hazel Plus NIPS
We spent the last decade pioneering the development and commercialization of non-invasive prenatal screening. Here are the 8 things that you should know about non-invasive prenatal screening before you order.
Juno’s Hazel™ laboratory developed test has been evaluated for clinical performance in multiple studies, inclusive of >1,600 total venous and capillary samples*. Based on this data, expected performance with at-home self collection is >99% sensitivity and >99.9% specificity for trisomy 21, 18, and 13.
Order your test: Place your order, and we'll quickly get a test kit to your doorstep. While you wait, you can schedule your Sample Collection Zoom Call with our experts!
Collect your sample: During your Sample Collection Zoom Call, our Customer Care Team will walk through a painless finger prick and simple sample collection process.
Get your results: Once your kit returns to our CLIA-certified laboratory, we will process your sample and deliver results within 2 business days.
You've got questions, we've got answers...
What is the Hazel™ Plus Non-Invasive Prenatal Screen?
The Hazel™ Plus Non-Invasive Prenatal Screen (NIPS) is a blood-based screening test for pregnant parents. In addition to screening for chromosomal trisomies seen commonly in pregnancy – Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Patau syndrome (trisomy 13) – Hazel™ Plus also screens for differences in the number of sex chromosomes. Collectively, these conditions are known as sex chromosome aneuploidies.
Hazel™ Plus can be performed as early as nine (9) weeks gestation through a simple blood collection which can be completed at home.
What is the difference between Hazel™ Basic and Hazel™ Plus?
Hazel™ Basic and Hazel™ Plus both use Juno’s advanced technology to screen your pregnancy for the common trisomies – Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Patau syndrome (trisomy 13) – and fetal sex.
In addition to screening for the common trisomies and fetal sex, Hazel™ Plus screens for sex chromosome aneuploidies. These conditions occur when there’s a different number of X or Y chromosomes than seen in most people – usually, females have two X chromosomes, and males have one X and one Y chromosome. Since some sex chromosome aneuploidies may not be recognized until later in life, Hazel™ Plus helps you plan and prepare by learning sex chromosome aneuploidy information in advance.
What are sex chromosome aneuploidies?
Sex chromosome aneuploidy means a person has extra or missing sex chromosomes. Females typically have two X sex chromosomes (XX), and males typically have one X sex chromosome and one Y sex chromosome (XY). So, a female with a sex chromosome aneuploidy might have one X, or three Xs, rather than the two Xs that are usually seen. A male with a sex chromosome aneuploidy may have two Xs and one Y chromosome (XXY), or one X and two Y chromosomes (XYY), in contrast to the one X and one Y seen in most males.
When a baby is born with a sex chromosome aneuploidy, they’ll usually look like other baby girls or baby boys at birth – doctors can’t tell based on their genitalia alone. As they grow up, a person with a sex chromosome aneuploidy may be taller or shorter than average and can have puberty problems or infertility. Sex chromosome aneuploidies do not typically cause intellectual disability, but learning difficulties such as dyslexia can occur. These features can be subtle and may not be recognized for many years. While people with sex chromosome aneuploidies may have some features in common, each condition is associated with slightly different features.
You can learn more about sex chromosome aneuploidies in our video here.
Can I order Hazel™ Plus for myself, or does it need to be ordered by my doctor?
You can order the Hazel™ Plus Non-Invasive Prenatal Screening Test directly through our website. Because Hazel™ Plus is a medical screen, a physician will review your order before we ship a kit to you. Alternatively, your prenatal care provider can order Hazel™ Plus on your behalf directly from Juno. If they don’t have an account at Juno, they can contact us directly at firstname.lastname@example.org
How early can I take Hazel™ Plus?
The Hazel™ Plus Non-Invasive Prenatal Screening Test can be performed as early as 9 weeks into your pregnancy, counting from the first day of your last menstrual period.
When will I receive my results?
Once the JunoDx lab receives a Hazel™ Plus sample, results are typically available within 2-4 business days. At that time, you’ll get an email notification and be able to view your results in your myJuno portal.
How accurate are the results of Hazel™ Plus?
The Juno Hazel™ Non-Invasive Prenatal Screen has a >99% sensitivity and specificity for trisomy 21, 18, and 13 when patients follow our easy, video-assisted process for collection.