The Hazel™ Plus Non-Invasive Prenatal Screen (NIPS) is a blood-based screening test for pregnant parents. In addition to screening for chromosomal trisomies seen commonly in pregnancy – Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Patau syndrome (trisomy 13) – Hazel™ Plus also screens for differences in the number of sex chromosomes. Collectively, these conditions are known as sex chromosome aneuploidies. 

Hazel™ Plus can be performed as early as nine (9) weeks gestation through a simple blood collection which can be completed at home.

Hazel™ Basic and Hazel™ Plus both use Juno’s advanced technology to screen your pregnancy for the common trisomies – Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Patau syndrome (trisomy 13) – and fetal sex. 

In addition to screening for the common trisomies and fetal sex, Hazel™ Plus screens for sex chromosome aneuploidies. These conditions occur when there’s a different number of X or Y chromosomes than seen in most people – usually, females have two X chromosomes, and males have one X and one Y chromosome. Since some sex chromosome aneuploidies may not be recognized until later in life, Hazel™ Plus helps you plan and prepare by learning sex chromosome aneuploidy information in advance.

Sex chromosome aneuploidy means a person has extra or missing sex chromosomes. Females typically have two X sex chromosomes (XX), and males typically have one X sex chromosome and one Y sex chromosome (XY). So, a female with a sex chromosome aneuploidy might have one X, or three Xs, rather than the two Xs that are usually seen. A male with a sex chromosome aneuploidy may have two Xs and one Y chromosome (XXY), or one X and two Y chromosomes (XYY), in contrast to the one X and one Y seen in most males. 

When a baby is born with a sex chromosome aneuploidy, they’ll usually look like other baby girls or baby boys at birth – doctors can’t tell based on their genitalia alone. As they grow up, a person with a sex chromosome aneuploidy may be taller or shorter than average and can have puberty problems or infertility. Sex chromosome aneuploidies do not typically cause intellectual disability, but learning difficulties such as dyslexia can occur. These features can be subtle and may not be recognized for many years. While people with sex chromosome aneuploidies may have some features in common, each condition is associated with slightly different features.

You can learn more about sex chromosome aneuploidies in our video here. 

You can order the Hazel™ Plus Non-Invasive Prenatal Screening Test directly through our website. Because Hazel™ Plus is a medical screen, a physician will review your order  before we ship a kit to you. Alternatively, your prenatal care provider can order Hazel™ Plus on your behalf directly from Juno. If they don’t have an account at Juno, they can contact us directly at support@junodx.com

The Hazel™ Plus Non-Invasive Prenatal Screening Test can be performed as early as 9 weeks into your pregnancy, counting from the first day of your last menstrual period.

Once the JunoDx lab receives a Hazel™ Plus sample, results are typically available within 2-4 business days. At that time, you’ll get an email notification and be able to view your results in your myJuno portal.

The Juno Hazel™ Non-Invasive Prenatal Screen has a >99% sensitivity and specificity for trisomy 21, 18, and 13 when patients follow our easy, video-assisted process for collection.